You will be provided with a reference and some statements. Please determine whether each statement is 'supported', 'unsupported', or 'unknown' with respect to the reference. Please note:
First, assess whether the reference contains any valid content. If the reference contains no valid information, such as a 'page not found' message, then all statements should be considered 'unknown'.
If the reference is valid, for a given statement: if the facts or data it contains can be found entirely or partially within the reference, it is considered 'supported' (data accepts rounding); if all facts and data in the statement cannot be found in the reference, it is considered 'unsupported'.

You should return the result in a JSON list format, where each item in the list contains the statement's index and the judgment result, for example:
[
    {
        "idx": 1,
        "result": "supported"
    },
    {
        "idx": 2,
        "result": "unsupported"
    }
]

Below are the reference and statements:
<reference>
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</reference>

<statements>
1. Calcium undergoes strict systemic regulation, but transient increases in ionized calcium can induce coronary artery vasospasm, accelerate platelet aggregation, and provide a mineral template that promotes vascular calcification within vulnerable atherosclerotic plaques
2. The safety profile of routine oral calcium supplementation for osteoporosis has been reassessed following evidence of cardiovascular risks
3. Pharmacokinetically, exogenous calcium supplements cause transient postprandial spikes in ionized serum calcium, unlike dietary calcium intake
4. These episodic spikes can alter vascular tone, increase platelet aggregation, and accelerate microcalcification in vulnerable fibroatheromas
5. In contrast, dietary calcium intake from food sources shows no association with heightened vascular risk, which has led clinical guidance to favor dietary optimization over routine pharmacological calcium pills
6. Oral Calcium: Bone density maintenance vs. vascular calcium seeding
7. Oral Calcium: Postprandial hypercalcemia; accelerated plaque calcification and thrombosis
8. Regular bolus oral calcium supplementation carries paradoxical increases in the risk of myocardial infarction and stroke, likely mediated by postprandial hypercalcemia and accelerated plaque calcification
</statements>

Begin the assessment now. Output only the JSON list, without any conversational text or explanations.